Amitriptyline, doxepin, and imipramine have been associated with more weight gain than some other TCAs; nortriptyline and desipramine may be better tolerated.Some TCAs, such as amoxapine, are often listed as a TCA, but are in fact tetracyclic antidepressants.Antidepressants can directly affect how your brain senses certain kinds of pain.Also, if you have depression or anxiety, those meds can ease those symptoms, which can also help ease your pain.TCAs may also block the actions of other neurotransmitters, such as acetylcholine and histamine.Some TCAs affect these neurotransmitters more than others which explains why some TCAs work better for conditions other than depression or are more likely to cause side effects such as constipation, dry mouth, or sedation. Some people may experience side effects on dosages as low as 10 mg per day: jitteriness, irritation, unusual energy, and difficulty falling or staying asleep. One-third of panic-prone individuals become jittery and actually experience more anxiety symptoms for the first two to three weeks. The sedating side effects can limit productivity and concentration during the day. Consult your physician before using during pregnancy or breast-feeding. Start at 25 to 75 mg per day and increase over one or two weeks to an average dose of 75 to 150 mg and a maximum dose of 300 mg. Nausea and dizziness can be be common side effects. Some of these side effects will disappear with the passage of time or with a decrease in the dosage.
For this reason, the medication trial should probably be initiated with a very low dose -- as little as 10 to 25 milligrams (mg) per day of imipramine, for example. Typically taken in one dose at bedtime, but can be divided. Use during pregnancy or breast-feeding only after approval from your physician. Headache, drowsiness, dizziness, nervousness, trouble sleeping, dry mouth, nausea, vomiting, blurred vision, altered taste, sweating, stomach upset, constipation, loss of appetite, anxiety, or yawning may occur.
Tricyclic antidepressants (often abbreviated to TCAs) are a group of medicines that all have a similar structure and all work in a similar way.
They may be used for the treatment of other conditions, not only depression.
The anticholinergic effects of dry mouth, blurred vision, constipation, and difficulty in urination; postural hypotension; tachycardia, loss of sex drive; erectile failure; increased sensitivity to the sun; weight gain; sedation (sleepiness); increased sweating.
Men with an enlarged prostate should avoid certain antidepressants.